Global Suicide: A problem of health systems

It is estimated that over 800 000 people die by suicide and that there are many suicide attempts for each death. Young people are among those most affected. The numbers differ between countries, but it is the low- and middle-income countries that bear most of the global suicide burden, with an estimated 75% of all suicides occurring in these countries. The importance of each risk factor and the way it is classified will depend on each context. These factors can contribute to suicidal behaviours directly but can also contribute indirectly by influencing individual susceptibility to mental disorders. From the analysis of the rate of suicide, the numbers of suicide preventions successful with the number of hospitalizations and hospitalized for attempted suicide, it becomes possible to determine a path in order to create social change in three important factors to be followed to be fulfilled: knowledge (scientific and practical), public support (political will) and a social strategy, showing up as a national response to achieve the goals of suicide prevention

Palliative Sedation in Children and Adolescents: the Repercussion in the Family

Background: Estimative demonstrate about 6% of the 20 million people needing palliative care at the end of their life are less than 15 years old. Despite of that, researchers reported several areas of parent dissatisfaction with care including confusing, inadequate, or uncaring communications with clinicians regarding treatment or prognosis of the child’s end of life. Objective: Here we show that about 90% of the families that have a child or an adolescent passing through a situation that needs Palliative Sedation think that this process was necessary to relieve the suffering of the patient. Results: In several reports, parents of terminally ill children describe their perceptions of uncaring and insufficient communication from health care professionals and link that communication with their own lingering regrets and emotional distress. Conclusion: There is the necessity to better capacity the supportive and care team, in order to diminish guilty and grieve feelings, and to provide courses to the care team that can develop the communication process among them and the family

The Importance Of Neuronal Plasticity In The Prognosis Of Cases Of Cerebral Ischemia: A Systematic Review

Background: Neuronal plasticity is the capacity that the neurons have to make new connections and enable new ways of transmitting information. Under this context, new methodologies are being addressed in order to measure how important this neuronal capacity is in the process of full recovery of learning in subjects who suffered damage from cerebral ischemia.Methods: A systematic review was performed on the online databases: Medical Literature Analysis and Retrieval System Online (MEDLINE) and Scopus, between 1998 and 2014. The MeSH (Medical Subject Headings) descriptors used in this review were: "neuronal plasticity", "brain ischemia" and "learning". We found 164 articles that, when screened, resulted in 46 articles that met the criteria of evidence and were included in this review.Results: There are several ways available in the literature to increase neuronal plasticity to keep the learning process after bad conformations resulting from cerebral ischemia. We highlighted the most elucidated: those promoted by SMe1EC2 antioxidant, which brings therapeutic benefits when neuronal plasticity is impaired; and Atorvastatin, a statin which facilitates recovery of spatial learning. It is further observed that the body has a number of intrinsic devicessuch as the endogenous compensatory mechanisms that contribute to the development of neuronal plasticity when there is brain damage caused by ischemia.Conclusion: The improvement of neuronal plasticity appears in several studies mapped as a new and still little explored possibility of treatment of damages caused by brain processes of oxygen deprivation. Multiple devices, endogenous and exogenous, that promote an increase in neuronal plasticity, are being elucidated in an attempt to promote the full recovery of the learning process, decreased by brain damage from ischemic processes. Thus, it is pointed the necessity of scientific studies that allows to define and maximize the potentials of the neuronal plasticity

The HLA-DRB1 Alleles Effects on Multiple Sclerosis:a Systematic Review

Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that affects sensitive and motor functions. Many population studies were made with the intent of knowing better the most affected groups and the disease manifestations. These review analyses some of those studies, evaluating risk factors, especially genetic relations of Human Leukocyte Antigen DRB1 (HLADRB1) gens, for developing clinical disease.Method: We have analyzed 57 articles, published between 2009 and 2014, with the key words “multiple sclerosisâ€, “genetic association studies†and “HLA-DRB1 chainsâ€, through the Scopus database. Only 18 articles were eligible for our study; they were read entirely and included in the fial analysis.Results: Most studies imply genetic and environmental factors for the incidence of MS, its age of starting and prognosis. Previous studies have shown that many gens are related in MS pathogenesis and that interactions between them are important in determining clinicalmanifestations.Limitations: Different results were observed when different populations were targeted in the studies.Conclusion: There is an important relation between HLA-DRB1 and MS in diverse population groups. Complementary studies are needed to know better the importance of environmental factors and its interaction with gens in the development of MS